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Acne vulgaris is estimated to affect up to 10% of the world’s population.1 Recent literature has shown a significant decrease in side effects with isotretinoin treatment when combined with H1 antihistamines and a greater reduction in acneiform lesions.2,3 The purpose of this paper is to combine and analyze the results of pilot studies analyzing the reduction in skin purging in patient groups treated with a combination of H1 antihistamines and systemic retinoids.
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Osman et al. (2025) studied this question.
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