Evaluation of myocardial glucose metabolism in hypertrophic cardiomyopathy using 18F-fluorodeoxyglucose positron emission tomography

Figures

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  Fig 1. The degree of 18F-fluorodeoxyglucose (18F-FDG) uptake and the frequency of late gadolinium enhancement (LGE) at each LV 17 segment. (A) The 18F-FDG uptake in each type of HCM. The degree of 18F-FDG uptake was visually evaluated and semi-quantitatively scored using an uptake score (0: no uptake, 1: slight uptake, 2: mild uptake 3: moderate uptake, and 4: dense uptake). Light gray dot indicates the individual with slight uptake, middle gray dot mild uptake, dark gray dot moderate uptake, and black dot dense uptake. The mean uptake score was calculated in each segment and expressed by the density of gray color. (B) The frequency of LGE in HNCM and HOCM with LVOTO. The frequency of LGE was calculated in each LV segment and expressed by the density of gray color. The data of MVO and DHCM are not shown because only one patient per type received CMR.

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  Fig 2. The relationships between summed uptake score of 18F-FDG and clinical parameters. (A) The relationships between the summed uptake score and high-sensitive troponin T (HSTnT) level in HNCM patients (the left panel) and in HOCM patients (the right panel). (B) The relationships between the summed uptake score and brain natriuretic peptide (BNP) level in HNCM patients (the left panel) and in HOCM patients (the right panel).

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  Fig 3. A representative case of ASA. Images of serial 18F-FDG-positron emission tomography (PET)/computed tomography (CT) in a representative case of an HOCM patient who received alcohol septal ablation therapy (ASA). Ablated septal branches are indicated with yellow arrows in the upper panels. In the middle panels, long axis trans-vertical LV views of 18F-FDG-PET /CT before and after ASA are shown. An ablated myocardium is indicated with a star symbol, and the portion with a significant reduction of 18F-FDG uptake in the lateral and posterior LV wall is indicated with white arrows. In the lower table, the changes of the maximum standardized uptake value (SUV max) and summed uptake score are shown.

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  Fig 4. Change of 18F-FDG uptake score after ASA. Mean uptake score of 18F-FDG before and after ASA and difference score at each LV 17-segment. The mean uptake score was calculated with a semi-quantitative scoring method for each segment. Light gray dot indicates the individual with slight uptake, middle gray dot mild uptake, dark gray dot moderate uptake, and black dot dense uptake. The difference score was calculated by subtracting the post-value from the pre-value for each segment. The values were expressed by the density of gray color. * P<0.05 between pre- and post-ASA uptake score.