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October 14, 2002Archives of Internal MedicineOpen Access

The Prevention of Dementia With Antihypertensive TreatmentNew Evidence From the Systolic Hypertension in Europe (Syst-Eur) Study

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Why the study?

Does long-term antihypertensive therapy based on nitrendipine reduce the incidence of dementia in older patients with isolated systolic hypertension?

Population

2,902 patients aged ≥60 years with isolated systolic hypertension and no dementia at baseline.

Comparison

Antihypertensive therapy started immediately… vs Control group receiving placebo during the…

Design

RCT, randomized, double-blind, placebo-controlled initially, followed by…

Follow-up

median 3.9 years overall

Authors

FFFrançoise Forette

Discussion

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Overview

Supports antihypertensive initiation in older patients with isolated systolic hypertension to reduce dementia risk; extends cardiovascular trial benefits to cognitive outcomes.

Structured PICO

Does long-term antihypertensive therapy based on nitrendipine reduce the incidence of dementia in older patients with isolated systolic hypertension?

P
Population
2,902 patients aged ≥60 years with isolated systolic hypertension (systolic blood pressure 160-219 mm Hg, diastolic blood pressure <95 mm Hg) and no dementia at baseline.
I
Intervention
Antihypertensive therapy started immediately after randomization, consisting of nitrendipine (10-40 mg/d), with the possible addition of enalapril maleate (5-20 mg/d), hydrochlorothiazide (12.5-25 mg/d), or both.
C
Comparator
Control group receiving placebo during the initial double-blind phase, then offered active antihypertensive treatment after the trial ended.
O
Outcome
Incidence of dementiahard clinical

Long-term antihypertensive therapy initiated with a long-acting dihydropyridine significantly reduces the risk of incident dementia in older patients with isolated systolic hypertension.

Cite This Study

Françoise Forette (2002) studied this question.

synapsesocial.com/papers/69d56b5d75589c71d767ca82https://doi.org/10.1001/archinte.162.18.2046
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