Antihypertensive treatment may have reduced the rate of dementia in older patients with isolated systolic hypertension

Forette F, Seux ML, Staessen JA, et al, for the Syst-Eur Investigators. Prevention of dementia in randomised double-blind placebo-controlled systolic hypertension in Europe (Syst-Eur) trial. Lancet1998 Oct 24; 352 : 1347 –51 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Question In older patients with isolated systolic hypertension, can antihypertensive treatment prevent dementia? Randomised, double blind, placebo controlled trial with up to 5 years of follow up (an optional project in the systolic hypertension in Europe [Syst-Eur] trial). 106 centres in Europe. 2470 patients who were ≥60 years of age and had a systolic blood pressure (BP) (when seated) of 160–219 mm Hg and a diastolic BP <95 mm Hg. 2418 patients (98%) were analysed (mean age 70 y, 66% women). After stratification by sex, centre, and previous cardiovascular complications, patients were allocated to … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DForette%26rft.auinit1%253DF.%26rft.volume%253D352%26rft.issue%253D9137%26rft.spage%253D1347%26rft.epage%253D1351%26rft.atitle%253DPrevention%2Bof%2Bdementia%2Bin%2Brandomised%2Bdouble-blind%2Bplacebo-controlled%2BSystolic%2BHypertension%2Bin%2BEurope%2B%2528Syst-Eur%2529%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252898%252903086-4%26rft_id%253Dinfo%253Apmid%252F9802273%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(98)03086-4&link_type=DOI [3]: /lookup/external-ref?access_num=9802273&link_type=MED&atom=%2Febmental%2F2%2F3%2F77.atom [4]: /lookup/external-ref?access_num=000076691700013&link_type=ISI