Key result
Antihypertensive treatments yielded conflicting results for dementia prevention in elderly patients, with risk reductions of 55% and 19% in two trials but no significant difference in three others.
Why the study?
Do antihypertensive pharmacological treatments prevent the occurrence of dementia in elderly patients with hypertension?
Population
Subjects 60 years or older with hypertension
Comparison
Antihypertensive pharmacological treatments vs Placebo
Design
Review
Authors
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Conflicting trial results leave antihypertensive dementia prevention unresolved in the elderly; dedicated cognitive-outcome trials needed before practice change.
Do antihypertensive pharmacological treatments prevent the occurrence of dementia in elderly patients with hypertension?
Current evidence from randomized trials shows conflicting results regarding the efficacy of antihypertensive treatments in preventing dementia in the elderly, highlighting the need for future trials specifically designed to assess cognitive outcomes.
Igase et al. (2011) conducted a review in Hypertension and dementia. Antihypertensive pharmacological treatments vs. Placebo was evaluated on Incidence of dementia. Antihypertensive treatments yielded conflicting results for dementia prevention in elderly patients, with risk reductions of 55% and 19% in two trials but no significant difference in three others.
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