Why the study?
Does cisplatin-based chemotherapy induce acute cardiovascular changes (von Willebrand factor levels and carotid intima-media thickness) in patients with testicular cancer?
Does cisplatin-based chemotherapy induce acute cardiovascular changes (von Willebrand factor levels and carotid intima-media thickness) in patients with testicular cancer?
Cisplatin-based chemotherapy induces acute vascular changes in testicular cancer patients, which may have long-term prognostic significance for cardiovascular complications.
Suggests acute vascular injury from cisplatin in testicular cancer; leaves open long-term CV risk prediction and need for prospective studies.
In testicular cancer patients treated with cisplatin-based chemotherapy, we found an increase in plasma von Willebrand factor levels and in the intima-media thickness of the carotid artery. These changes may indicate chemotherapy-induced vascular damage and be of prognostic significance for the development of cardiovascular complications in the long term.
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Nuver et al. (2005) studied this question.
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