Key result
Chemotherapy used to treat testicular cancer may increase the risk of cardiovascular late effects, including Raynaud phenomenon, hypertension, hyperlipidemia, and coronary artery disease.
Why the study?
Does chemotherapy increase the risk of cardiovascular events and late effects in testicular cancer survivors?
Does chemotherapy increase the risk of cardiovascular events and late effects in testicular cancer survivors?
Chemotherapy for testicular cancer may increase the risk of late cardiovascular effects, highlighting the need for risk factor identification and patient education.
May warrant cardiovascular risk monitoring in testicular cancer survivors; leaves open need for prospective confirmation.
PURPOSE/OBJECTIVES: To explore what is known regarding cardiovascular late effects of treatment, such as Raynaud phenomenon, hypertension, hyperlipidemia, and coronary artery disease as well as the risk for cardiovascular events experienced by patients with testicular cancer treated with chemotherapy. DATA SOURCES: Literature review of treatment options and cardiovascular risk in patients with testicular cancer from PubMed, MEDLINE, oncology nursing literature, and the Internet. DATA SYNTHESIS: Evidence exists that chemotherapy used to treat testicular cancer may increase risk of cardiovascular disease. More research is needed to clarify the risks further. Patients and their healthcare providers must be aware of the potential toxicities. CONCLUSIONS: A limited but growing body of research is focused on defining cardiovascular risks in this population. IMPLICATIONS FOR NURSING: Nurses have an important role in exploring and identifying cardiovascular risk factors in patients, furthering research to clarify the risks, and using the knowledge to improve patient care and education.
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Zoltick et al. (2005) conducted a review in Testicular cancer. Chemotherapy was evaluated on Cardiovascular late effects. Chemotherapy used to treat testicular cancer may increase the risk of cardiovascular late effects, including Raynaud phenomenon, hypertension, hyperlipidemia, and coronary artery disease.
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