Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity
Why the study?
Does gallic acid pretreatment prevent cardiac hypertrophy and fibrosis in isoproterenol-induced mouse and cellular models?
Population
Mice, primary neonatal cardiomyocytes, cardiac myoblast H9c2 cells, and rat cardiac fibroblasts with…
Design
Preclinical
Authors
Discussion
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Implication
Supports further preclinical studies of gallic acid; leaves open translation to human cardiac hypertrophy or fibrosis.
Structured PICO
Does gallic acid pretreatment prevent cardiac hypertrophy and fibrosis in isoproterenol-induced mouse and cellular models?
P
Population
Mice, primary neonatal cardiomyocytes, cardiac myoblast H9c2 cells, and rat cardiac fibroblasts with isoproterenol (ISP)-induced cardiac hypertrophy
I
Intervention
Gallic acid pretreatment
O
Outcome
Concentric cardiac hypertrophy and interstitial collagen deposition (fibrosis)surrogate
Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis in preclinical models by modulating JNK2 and Smad3 signaling pathways.
Cite This Study
Ryu et al. (2016) studied this question.