Why the study?
Does serial proton MR spectroscopy reveal progressive gray and white matter abnormalities over time in patients with relapsing-remitting MS?
Does serial proton MR spectroscopy reveal progressive gray and white matter abnormalities over time in patients with relapsing-remitting MS?
Serial proton MR spectroscopy reveals that in relapsing-remitting MS, white matter glial abnormalities progress despite immunomodulatory treatment, while axonal dysfunction may partially recover.
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Progressive glial changes may evade standard monitoring in treated RRMS; leaves open whether serial MRS refines disease tracking.
Kirov et al. (2012) studied this question.
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