Why the study?
Does timolol reduce mortality and reinfarction in patients ages 65-75 years surviving acute myocardial infarction?
Population
732 patients ages 65-75 years who survived acute myocardial infarction
Comparison
Timolol 10 mg twice daily vs Placebo
Design
RCT
Follow-up
12-33 months (mean 17 months)
Authors
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Supports beta-blocker use after MI in patients aged 65-75; extends mortality benefit evidence to older adults.
Does timolol reduce mortality and reinfarction in patients ages 65-75 years surviving acute myocardial infarction?
Timolol significantly reduces mortality and reinfarction in older post-MI patients (65-75 years), demonstrating that advanced age should not preclude beta-blocker therapy after myocardial infarction.
Gundersen et al. (1982) studied this question.
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