In uremic mice, cardiac and aortic dysfunction are driven by subendothelial dysfunction and CRF severity rather than structural aortic calcification or hypercholesterolemia.
Subendothelial dysfunction may drive cardiac and aortic changes in uremia; hypothesis-generating in mice, needs human validation.
In a mouse model of CRF, left ventricular hypertrophy, cardiac diastolic dysfunction, and increased aortic stiffness were not related to structural changes in the aorta (including aortic calcification) or high serum cholesterol levels. However, cardiac and aortic abnormalities were associated with the extent of subendothelial dysfunction and the severity of CRF.
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Maizel et al. (2009) studied this question.
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