Key result
In patients with end-stage renal disease, lower-limb PWV was independently correlated with plasma total homocysteine and plasma endothelin levels.
Why the study?
Do biochemical alterations in ESRD patients correlate with increased arterial stiffness and cardiac mass?
Population
Stable end-stage renal disease patients on hemodialysis and nonuremic control subjects similar in age, sex…
Comparison
End-stage renal disease and associated… vs Nonuremic control subjects
Design
Case-control, Cardiac measurements were performed in a blinded fashion by two…
Authors
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May link homocysteine and endothelin to arterial stiffness in ESRD; leaves open causal role and need for interventional trials.
Do biochemical alterations in ESRD patients correlate with increased arterial stiffness and cardiac mass?
In patients with end-stage renal disease, arterial stiffness and cardiac mass are strongly influenced by biochemical factors such as homocysteine and endothelin, independent of age and blood pressure.
Blacher et al. (1998) studied this question. In patients with end-stage renal disease, lower-limb PWV was independently correlated with plasma total homocysteine and plasma endothelin levels.
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