Key result
Age, mean arterial pressure, and diabetes were identified as the strongest independent determinants of higher arterial stiffness (adjusted R2 = 0.29) in patients with chronic kidney disease stage 3.
Cross-Sectional (n=1,717)
Yes
Effect estimate: Adjusted R2 = 0.29
p-value: p=<0.001
In patients with early chronic kidney disease, traditional cardiovascular risk factors rather than renal function parameters are the primary determinants of arterial stiffness.
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Traditional risks predominate in stage 3 CKD stiffness; hypothesis-generating and should not yet change practice.
McIntyre et al. (2013) conducted a cross-sectional in Chronic Kidney Disease Stage 3 (n=1,717). Cardiovascular risk factors (age, mean arterial pressure, diabetes) was evaluated on Aortic pulse wave velocity (aPWV) (Adjusted R2 = 0.29, p=<0.001). Age, mean arterial pressure, and diabetes were identified as the strongest independent determinants of higher arterial stiffness (adjusted R2 = 0.29) in patients with chronic kidney disease stage 3.
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