Why the study?
Does end-stage renal disease since childhood increase arterial stiffness in young adults compared to healthy controls?
Population
130 Dutch young adults with onset of end-stage renal disease between 1972 and 1992 at age 0 to 14 years.
Comparison
End-stage renal disease (ESRD) since childhood vs 48 age-matched and gender-matched healthy controls
Design
Cross-sectional
Authors
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Pediatric-onset ESRD was associated with increased arterial stiffness in young adults; hypothesis-generating for CV risk modification trials.
Does end-stage renal disease since childhood increase arterial stiffness in young adults compared to healthy controls?
Young adults with pediatric-onset ESRD exhibit significantly increased carotid arterial stiffness compared to healthy controls, with hypertension identified as a major determinant.
Groothoff et al. (2002) studied this question.