What question did this study set out to answer?

Examine how chronic inflammation and immune cellular pathways drive the initiation, progression, and destabilization of atherosclerotic plaques in cardiovascular disease.

October 26, 2022SHILAP Revista de lepidopterologíaOpen Access

The Role of Inflammation in Cardiovascular Disease

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Authors

MHMichael Y. HeneinCardiac Imaging SVSergio VancheriCentre Hospitalier Universitaire de Besançon GLGiovanni LongoGeorge Eliot Hospital

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Implication

Narrative review outlines cytokine-driven plaque destabilization and systemic triggers in cardiovascular disease, indicating therapeutic promise alongside infection risks.

Key Points

Examine how chronic inflammation and immune cellular pathways drive the initiation, progression, and destabilization of atherosclerotic plaques in cardiovascular disease.
Synthesized molecular mechanisms linking immune cellular recruitment, cytokine signaling (IL-1β, IL-6, IL-12), and modified lipoprotein accumulation in the arterial wall.
Evaluated physiological drivers of systemic vascular inflammation, including psychological stress, clonal expansion during aging, and targeted cytokine-blocking interventions.
Endothelial dysfunction increases lipid permeability and triggers macrophage infiltration, generating necrotic lipid cores that erode collagen caps into vulnerable thin-cap fibro-atheromas.
Psychological stress via sympathetic stimulation and clonal hematopoiesis in aging exacerbate cardiovascular risk through sustained peripheral cytokine secretion.
Targeted cytokine inhibition lowers the risk of myocardial infarction and stroke, though it systematically elevates vulnerability to infectious complications.

Cite This Study

Henein et al. (2022) studied this question.

synapsesocial.com/papers/69d56ce775589c71d767ce81 https://doi.org/10.3390/ijms232112906

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Implication

Narrative review outlines cytokine-driven plaque destabilization and systemic triggers in cardiovascular disease, indicating therapeutic promise alongside infection risks.

The Role of Inflammation in Cardiovascular Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

The Role of Inflammation in Cardiovascular Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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