Why the study?
Does higher beta blocker dose reduce mortality in heart failure patients?
Does higher beta blocker dose reduce mortality in heart failure patients?
In heart failure patients, higher beta blocker doses are associated with lower mortality, and cardiac 123 I-mIBG uptake serves as a powerful prognostic marker.
May support higher beta blocker dosing in HF; leaves open causal effects and mIBG-guided risk stratification.
Higher beta blocker dose was associated with lower mortality, but of the variables associated with sympathetic activity examined, cardiac ¹²³ I-mIBG uptake was the most powerful prognostic marker in heart failure patients. Elevated heart rate was associated with greater risk for cardiac death.
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Cohen‐Solal et al. (2017) studied this question.
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