March 6, 2013JAMA
Association of Fibrosis With Mortality and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy
Why the study?
Does assessment of midwall fibrosis with LGE-CMR imaging predict mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy?
Population
Patients with nonischemic dilated cardiomyopathy
Design
Cohort
Authors
Discussion
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Member takes
Implication
May enhance risk stratification beyond LVEF in nonischemic cardiomyopathy; leaves open impact on therapy or outcomes.
Key Points
- This research aims to explore the relationship between midwall fibrosis and mortality in patients with nonischemic dilated cardiomyopathy.
- Used LGE-CMR imaging to assess midwall fibrosis
- Evaluated prognostic information beyond LVEF
- Investigated risk stratification roles for dilated cardiomyopathy
- LGE-CMR provided independent prognostic information alongside LVEF measurements
- High levels of midwall fibrosis correlates with increased mortality rates
- Further investigations needed to clarify fibrosis's role in risk stratification
Structured PICO
Does assessment of midwall fibrosis with LGE-CMR imaging predict mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy?
P
Population
Patients with nonischemic dilated cardiomyopathy
I
Intervention
Assessment of midwall fibrosis with LGE-CMR (Late Gadolinium Enhancement Cardiovascular Magnetic Resonance) imaging
O
Outcome
Mortality and sudden cardiac deathhard clinical
LGE-CMR imaging of midwall fibrosis provides independent prognostic value beyond LVEF for mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy.
Cite This Study
Gulati et al. (2013) studied this question.