October 13, 2006Science

5'-Triphosphate RNA Is the Ligand for RIG-I

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Population

In vitro/preclinical models (cells, viral RNA, RIG-I protein)

Comparison

5'-triphosphate RNA (3pRNA) vs Capped RNA, nucleoside-modified RNA, RNA from…

Design

Preclinical

Authors

Discussion

May inform RNA therapeutic design to evade interferon responses; leaves open human translation from animal models.

Population

In vitro/preclinical models (cells, viral RNA, RIG-I protein)

Intervention

5'-triphosphate RNA (3pRNA)

Comparator

Capped RNA, nucleoside-modified RNA, RNA from noninfected cells

Outcome

RIG-I-mediated detection and interferon-alpha responsesurrogate

Uncapped 5'-triphosphate RNA serves as the molecular signature for the detection of viral infection by RIG-I.

Hornung et al. (2006) studied this question.

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