Progressive histologic changes in pulmonary arteries are detailed, indicating significant clinical implications in patients with congenital heart defects.
Progressive histologic changes occur in the pulmonary arteries and arterioles, as a complication of chronically elevated pulmonary arterial blood pressure, in patients with congenital septal defects of the heart. This progression is so stereotyped as to allow a division of the structural effects into 6 grades. The histologic features of each grade are described in detail in this communication. These results afford a basis for comparing the magnitude of these changes to the clinical findings.
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Heath et al. (1958) studied this question.
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