What question did this study set out to answer?

This study aims to analyze the morphology and distribution of epicardiac neural plexus in the human heart.

January 1, 2000The Anatomical RecordOpen Access

Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart

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Population

Whole hearts of 21 humans (including fetuses, neonates, children, and adults)

Design

Preclinical

Authors

DPDainius H. PaužaLithuanian University of Health Sciences VSValdas SkripkaLithuanian University of Health Sciences NPNeringa PauzieneLithuanian University of Health Sciences

Discussion

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Implication

May guide future arrhythmia neuromodulation; hypothesis-generating for age-related neuronal loss and requires clinical validation.

Key Points

This study aims to analyze the morphology and distribution of epicardiac neural plexus in the human heart.
Histochemical analysis for acetylcholinesterase in whole hearts of 21 humans
Examination via stereoscopic, contact, and bright-field microscopy
Criteria established to distinguish ganglionated subplexuses
Number of epicardiac ganglia ranged from 706 to 1,560 with an average of 836 +/- 76 across hearts
Highest density of ganglia found near the heart hilum, especially on the left atrium
Approximately 43,000 intrinsic neurons present in adult hearts and 94,000 in young hearts

Structured PICO

Population

Whole hearts of 21 humans (including fetuses, neonates, children, and adults)

Intervention

Histochemical method for acetylcholinesterase and examination by stereoscopic, contact, and bright-field microscopy

Outcome

Topography and structure of the human epicardiac neural plexus (ENP) as a system of seven ganglionated subplexusessurrogate

This anatomical study maps the topography of the human epicardiac neural plexus, revealing an average of 836 epicardiac ganglia and an age-related decline in the number of intrinsic neurons, providing a morphological framework relevant to the surgical treatment of cardiac arrhythmias.

Cite This Study

Pauža et al. (2000) studied this question.

synapsesocial.com/papers/69d56dda75589c71d767d136 https://doi.org/10.1002/1097-0185(20000801)259:4<353::aid-ar10>3.0.co;2-r

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Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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