June 3, 1997Circulation
Efferent Vagal Innervation of the Canine Atria and Sinus and Atrioventricular Nodes
Why the study?
Does elimination of the SVC-Ao fat pads with RFCA cause selective vagal denervation of the atria and sinus and AV nodes in a canine model?
Population
Canine model
Design
Preclinical
Authors
Discussion
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Implication
Should not yet influence human AF ablation; hypothesis-generating for selective vagal denervation in patients.
Key Points
- To identify the pathway of efferent vagal innervation to the canine atria and conduction nodes and assess the effect of targeted fat pad ablation.
- Examined efferent vagal nerve projections through the superior vena cava-aorta (SVC-Ao) fat pad in a canine model.
- Applied radiofrequency catheter ablation (RFCA) to selectively eliminate targeted cardiac fat pads.
- The SVC-Ao fat pad was determined to receive the majority of efferent vagal fibers supplying the atria, sinus node, and atrioventricular node.
- Elimination of the SVC-Ao fat pads via RFCA achieved selective vagal denervation across the atria as well as the sinus and atrioventricular nodes.
Structured PICO
Does elimination of the SVC-Ao fat pads with RFCA cause selective vagal denervation of the atria and sinus and AV nodes in a canine model?
P
Population
Canine model
I
Intervention
Elimination of the SVC-Ao fat pads with radiofrequency catheter ablation (RFCA)
O
Outcome
Vagal denervation of the atria and sinus and AV nodessurrogate
Radiofrequency catheter ablation of the newly described SVC-Ao fat pad selectively vagally denervates the atria, sinus, and AV nodes in canines.
Cite This Study
Chiou et al. (1997) studied this question.