Why the study?
Tirofiban is frequently used in contemporary cardiovascular care, but it is associated with thrombocytopenia whose pathogenesis is not entirely understood.
Tirofiban-induced thrombocytopenia is a concerning immune-mediated adverse reaction that requires awareness regarding its pathophysiology, presentation, and management in contemporary cardiovascular care.
Clinicians should monitor platelets with tirofiban; review leaves open optimal prevention strategies.
Tirofiban is a small non-peptide ligand-mimetic Glycoprotein (GP) IIb/IIIa inhibitor which can reversibly bind to the arginine-glycine-aspartic acid (RGD) recognition site of GP IIb/IIIa to prevent platelet aggregation. It reduces the incidence of thrombotic cardiovascular events in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Although generally considered safe, tirofiban has been reported to be associated with thrombocytopenia in several case reports and clinical trials. The pathogenesis for this adverse reaction is not entirely understood, is thought to be due to immune-mediated reaction. This side effect caused by tirofiban is especially concerning given how frequently it is used in the practice of contemporary cardiovascular care. The present review provides an overview of the pathophysiology, clinical presentation, management, and risk factors associated with tirofiban-induced thrombocytopenia.
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Wang et al. (2023) studied this question.
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