What question did this study set out to answer?

To evaluate age-related changes in pulsatile arterial function and determine how pulse contour analysis reflects variations in arterial compliance.

June 1, 1999HypertensionOpen Access

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

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Why the study?

How does aging affect large artery and oscillatory compliance as measured by pressure pulse contour analysis in healthy volunteers?

Population

327 healthy normotensive volunteers, comprising 115 evaluated invasively and 212 evaluated noninvasively.

Design

Cross-sectional

Authors

GMGary E. McVeighQueen's University Belfast CBChristopher W. BratteliUniversity of Minnesota DMDennis J. MorganAbbott (United States)

Discussion

Member takes

Implication

Age-related compliance decline may mark vascular aging; leaves open prospective validation as independent prognostic tool.

Key Points

To evaluate age-related changes in pulsatile arterial function and determine how pulse contour analysis reflects variations in arterial compliance.
Analyzed intra-arterial brachial artery waveforms in 115 healthy normotensive volunteers (83 men, 32 women) and radial artery tonometer waveforms in 212 healthy volunteers (147 women, 65 men).
Quantified arterial waveform dynamics into large artery (capacitive) compliance, small artery (oscillatory) compliance, inertance, and systemic vascular resistance using diastolic pressure decay and a modified Windkessel model.
Large artery compliance and oscillatory compliance correlated negatively with age in both invasive (r = -0.50 and r = -0.55; P < 0.001) and noninvasive cohorts (r = -0.37 and r = -0.66; P < 0.001).
Regression slopes showing the decline of oscillatory compliance with age were significantly steeper than those observed for large artery compliance.
Age-associated blood pressure changes independently contributed to large artery compliance decline, whereas oscillatory compliance reduction occurred independently of blood pressure changes.

Structured PICO

How does aging affect large artery and oscillatory compliance as measured by pressure pulse contour analysis in healthy volunteers?

Population

327 healthy normotensive volunteers, comprising 115 evaluated invasively (83 men, 32 women) and 212 evaluated noninvasively (147 women, 65 men).

Outcome

Age-related changes in large artery (capacitive) compliance and oscillatory (reflective) compliance derived from pressure pulse contour analysissurrogate

Oscillatory compliance declines more steeply with age than large artery compliance and is independent of blood pressure changes, making it a potentially better marker of vascular aging.

Cite This Study

McVeigh et al. (1999) studied this question.

synapsesocial.com/papers/69d56dfe75589c71d767d28d https://doi.org/10.1161/01.hyp.33.6.1392

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Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider