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November 21, 2006ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Angiotensin-(1-7) Through Receptor Mas Mediates Endothelial Nitric Oxide Synthase Activation via Akt-Dependent Pathways

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Population

Chinese hamster ovary cells stably transfected with Mas cDNA and human aortic endothelial cells

Comparison

Angiotensin-(1-7) (10(-7) mol/L; 1 to 30 minutes) vs Control (absence of Ang-) and presence of…

Design

Preclinical

Authors

WSWalkyria Oliveira SampaioVascular MedicineRSRobson A.S. SantosGeneral CardiologyRFRaphael Faria-SilvaUniversidade Federal de Minas Gerais

Discussion

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Implication

Hypothesis-generating for Mas receptor agonism in endothelial function; human studies needed before any clinical consideration.

Structured PICO

P
Population
Chinese hamster ovary cells stably transfected with Mas cDNA (Chinese hamster ovary-Mas) and human aortic endothelial cells
I
Intervention
Angiotensin-(1-7) (10(-7) mol/L; 1 to 30 minutes)
C
Comparator
Control (absence of Ang-(1-7)) and presence of antagonists A-779 (10(-6) mol/L) or wortmannin (10(-6) mol/L)
O
Outcome
eNOS activation (phosphorylation at Ser1177/Thr495), Akt phosphorylation, and NO releasesurrogate

Ang-(1-7) stimulates eNOS activation and NO production via Akt-dependent pathways through the Mas receptor, highlighting its role in regulating endothelial function.

Cite This Study

Sampaio et al. (2006) studied this question.

synapsesocial.com/papers/69d56e0675589c71d767d2e4https://doi.org/10.1161/01.hyp.0000251865.35728.2f
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Also Consider

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  4. 4Evidence for a Functional Interaction of the Angiotensin-(1–7) Receptor Mas With AT 1 and AT 2 Receptors in the Mouse Heart2005 · 168 citations
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