Why the study?
Does VKA compared to LMWH improve maternal and fetal outcomes in pregnant women with mechanical heart valves?
Does VKA compared to LMWH improve maternal and fetal outcomes in pregnant women with mechanical heart valves?
In pregnant women with mechanical heart valves, VKA minimizes maternal risk while LMWH minimizes fetal risk, though low-dose warfarin (≤5 mg daily) has similar fetal risk to LMWH.
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Supports individualized anticoagulation balancing maternal-fetal risks in mechanical valve pregnancies; leaves open confirmation by randomized trials.
Steinberg et al. (2017) studied this question.
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