November 11, 2015Open Access
View Full PaperAndexanet Alfa for the Reversal of Factor Xa Inhibitor Activity
Structured PICO
Does andexanet alfa reverse the anticoagulant activity of apixaban and rivaroxaban in older healthy participants?
P
Population
older healthy participants
I
Intervention
Andexanet alfa
O
Outcome
reversal of the anticoagulant activity of apixaban and rivaroxabansurrogate
Andexanet alfa rapidly and safely reverses the anticoagulant activity of factor Xa inhibitors apixaban and rivaroxaban in older healthy participants.
Abstract
Andexanet reversed the anticoagulant activity of apixaban and rivaroxaban in older healthy participants within minutes after administration and for the duration of infusion, without evidence of clinical toxic effects. (Funded by Portola Pharmaceuticals and others; ANNEXA-A and ANNEXA-R ClinicalTrials.gov numbers, NCT02207725 and NCT02220725.).