Does andexanet alfa reverse the anticoagulant activity of apixaban and rivaroxaban in older healthy participants?
Andexanet alfa rapidly and safely reverses the anticoagulant activity of factor Xa inhibitors apixaban and rivaroxaban in older healthy participants.
Andexanet reversed the anticoagulant activity of apixaban and rivaroxaban in older healthy participants within minutes after administration and for the duration of infusion, without evidence of clinical toxic effects. (Funded by Portola Pharmaceuticals and others; ANNEXA-A and ANNEXA-R ClinicalTrials.gov numbers, NCT02207725 and NCT02220725.).
Siegal et al. (2015) studied this question.