December 21, 2015Expert Review of Hematology
Andexanet alfa for the reversal of Factor Xa inhibitor related anticoagulation
Why the study?
Does andexanet alfa reverse Factor Xa inhibition and restore thrombin generation?
Population
Ex vivo models, animals, and human volunteers
Design
Review
Authors
Discussion
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Member takes
Implication
Andexanet alfa restores thrombin generation in volunteer studies; leaves open clinical safety and efficacy pending larger trials.
Structured PICO
Does andexanet alfa reverse Factor Xa inhibition and restore thrombin generation?
P
Population
Ex vivo models, animals, and human volunteers (with further trials underway in patients experiencing FXa inhibitor-related bleeding)
I
Intervention
Andexanet alfa
O
Outcome
Reversal of Factor Xa inhibition and restoration of thrombin generationsurrogate
Andexanet alfa acts as a specific reversal agent for Factor Xa inhibitors by restoring thrombin generation without triggering prothrombotic activity.
Cite This Study
Ghadimi et al. (2015) studied this question.