Key result
Andexanet alfa is a factor Xa decoy developed to reverse multiple anti-factor Xa medications, including apixaban, edoxaban, rivaroxaban, and low-molecular-weight heparins.
Why the study?
Does andexanet alfa reverse the anticoagulant effects of factor Xa inhibitors?
Population
Patients receiving anti-factor Xa direct oral anticoagulants or indirect FXa inhibitors
Design
Review
Authors
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Provides a targeted reversal option for life-threatening bleeding on factor Xa inhibitors;.
Does andexanet alfa reverse the anticoagulant effects of factor Xa inhibitors?
Andexanet alfa is a factor Xa decoy developed as a specific reversal agent for direct and indirect factor Xa inhibitors.
Kaatz et al. (2017) conducted a review in Anticoagulation reversal. Andexanet alfa was evaluated. Andexanet alfa is a factor Xa decoy developed to reverse multiple anti-factor Xa medications, including apixaban, edoxaban, rivaroxaban, and low-molecular-weight heparins.
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