Why the study?
Does exercise protect cardiac mitochondria against ischemia-reperfusion injury?
Does exercise protect cardiac mitochondria against ischemia-reperfusion injury?
Exercise induces mitochondrial adaptations that protect the heart against ischemia-reperfusion injury.
Hypothesis-generating for mitochondrial cardioprotection strategies; leaves open translation to human exercise interventions.
Collectively, these novel findings reveal that exercise-induced cardioprotection is mediated, at least in part, through mitochondrial adaptations resulting in a mitochondrial phenotype that resists IR-induced damage.
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Lee et al. (2011) studied this question.
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