What question did this study set out to answer?

To evaluate the role of asymmetric dimethylarginine (ADMA) in causing endothelial dysfunction and its utility as an independent biomarker for cardiovascular disease.

April 22, 2010Current Cardiology ReviewsOpen Access

The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease

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Design

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Authors

LSLatika SibalLeeds General Infirmary SASharad AgarwalRoyal Jubilee Hospital PHPhilip HomeNewcastle University

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Implication

ADMA is a strong independent risk marker; leaves open whether modifying levels improves cardiovascular outcomes.

Key Points

To evaluate the role of asymmetric dimethylarginine (ADMA) in causing endothelial dysfunction and its utility as an independent biomarker for cardiovascular disease.
Synthesized biological mechanisms linking elevated circulating asymmetric dimethylarginine (ADMA) to nitric oxide synthase inhibition.
Assessed clinical evidence evaluating ADMA as an independent predictor of cardiovascular events, all-cause mortality, and response to L-arginine therapy.
Elevated ADMA inhibits nitric oxide synthesis, directly impairing endothelium-dependent vasodilation and accelerating atherosclerosis development.
High circulating ADMA levels serve as a strong independent risk predictor of all-cause and cardiovascular mortality in patients with coronary artery disease.
Exogenous L-arginine administration improves endothelium-mediated vasodilatation in patients with elevated ADMA, though the clinical utility of lowering ADMA remains unconfirmed.

Cite This Study

Sibal et al. (2010) studied this question.

synapsesocial.com/papers/69d56e2b75589c71d767d489 https://doi.org/10.2174/157340310791162659

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The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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