Why the study?
The clinical use of the antineoplastic drug doxorubicin is limited by cardiotoxicity, prompting evaluation of nerolidol's cardioprotective effects and molecular mechanisms.
Does nerolidol attenuate doxorubicin-induced chronic cardiotoxicity in a rat model?
Population
Male albino Wistar rats with DOX-induced chronic cardiotoxicity
Comparison
NERO treatment vs untreated DOX-injected rats
Design
Animal experimental study
Follow-up
5 weeks
Authors
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Nerolidol showed protective effects in rat doxorubicin cardiotoxicity; leaves open clinical translation and human trials.
Does nerolidol attenuate doxorubicin-induced chronic cardiotoxicity in a rat model?
Nerolidol attenuates doxorubicin-induced chronic cardiotoxicity in rats by reducing oxidative stress, inflammation, and apoptosis.
Meeran et al. (2021) studied this question.
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