Why the study?
Calcific aortic valve disease is the most prevalent valvular heart disease in the developed world, but no pharmacological therapy exists.
Integrative multi-omics analysis identifies a novel molecular network in calcific aortic valve disease linked to amyloid-like deposits, highlighting APP and TTR as potential therapeutic targets.
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May implicate APP and TTR in calcific aortic valve disease; hypothesis-generating from animal multi-omics data.
Heuschkel et al. (2020) studied this question.
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