Why the study?
Renal cell carcinoma commonly metastasizes to organs such as the lungs, liver, bones, and brain, but isolated metastases to the head and neck region, especially the larynx, are very rare.
This case highlights the rarity of laryngeal metastasis from renal cell carcinoma and the importance of accurate diagnosis through advanced imaging and histopathological examination.
Supports multimodal therapy for rare laryngeal RCC metastasis; leaves open generalizability pending larger studies.
Renal cell carcinoma (RCC) commonly metastasizes to various organs such as the lungs, liver, bones, and brain. However, isolated metastases to the head and neck region, especially the larynx, are very rare. This report presents a case of laryngeal growth that was eventually confirmed to be a metastatic deposit from an undiagnosed RCC. We report a case of a 66-year-old male who presented to the clinic with painless neck swelling and a change in voice. The scan showed a soft tissue mass in the thyroid cartilage. Histopathology of the resected laryngeal tumor confirmed metastatic clear cell carcinoma. A metastatic workup revealed a renal mass, and the patient underwent laparoscopic adrenal-sparing left cytoreductive nephrectomy. The histopathological examination established the diagnosis of clear cell RCC. Subsequently, the patient was treated with pembrolizumab and lenvatinib. Follow-up imaging showed no residual or recurrent lesions. This case highlights the rarity of laryngeal metastasis from RCC and the importance of an accurate diagnosis through advanced imaging and histopathological examination.
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Ahmed et al. (2023) studied this question.
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