Why the study?
Does intermittent repeated levosimendan infusions reduce hospital readmissions and improve survival in patients with advanced heart failure?
Does intermittent repeated levosimendan infusions reduce hospital readmissions and improve survival in patients with advanced heart failure?
Intermittent levosimendan in advanced heart failure significantly improved 12-month survival and reduced early decompensation or death, despite a non-significant reduction in overall hospital readmissions.
May support survival gains with intermittent levosimendan in advanced HF; extends equivocal RCT evidence and requires larger confirmatory trials.
In our study, intermittent levosimendan in patients with AdHF produced a statistically non-significant reduction in the incidence of hospital readmissions for acute decompensated HF, a significantly lower cumulative incidence of acute decompensation of HF and/or death at 1 and 3 month of treatment and a significant improvement in survival during 12 months of treatment.
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García‐González et al. (2021) studied this question.
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