What question did this study set out to answer?

To review the transcriptional mechanisms regulating pyruvate dehydrogenase kinase isoenzymes PDK2 and PDK4 across tissues during starvation and diabetes.

January 1, 2012SHILAP Revista de lepidopterologíaOpen Access

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase

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To review the transcriptional mechanisms regulating pyruvate dehydrogenase kinase isoenzymes PDK2 and PDK4 across tissues during starvation and diabetes.
Synthesized molecular evidence on hormonal, receptor, and nutrient-driven regulation of PDK2 and PDK4 expression in liver, skeletal muscle, heart, and kidney tissues.
Assessed signaling cascades including the insulin-mediated PI3K/Akt/FOXO axis, nuclear hormone receptors, and tissue-specific modulators such as adiponectin and rosiglitazone.
Insulin down-regulates PDK2 and PDK4 expression through PI3K/Akt-dependent phosphorylation of FOXO transcription factors.
Fasting and increased fat supply stimulate PDK2 and PDK4 expression via nuclear hormone receptors including PPARs, glucocorticoid receptors, estrogen-related receptors, and thyroid hormone receptors.
Growth hormone, adiponectin, epinephrine, and rosiglitazone exert tissue-specific transcriptional control over PDK4, contributing to metabolic disease pathogenesis.

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Implication

Review reveals transcriptional mechanisms controlling pyruvate dehydrogenase kinase 2 and 4 expression, highlighting signaling targets in diabetes and starvation.

Cite This Study

Jeong et al. (2012) studied this question.

synapsesocial.com/papers/69d56ee075589c71d767d747 https://doi.org/10.4093/dmj.2012.36.5.328

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Implication

Review reveals transcriptional mechanisms controlling pyruvate dehydrogenase kinase 2 and 4 expression, highlighting signaling targets in diabetes and starvation.

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase

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Discussion

Implication

Cite This Study

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase

Key Points

Discussion

Implication

Cite This Study

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