Why the study?
Does long-term renal denervation normalize disrupted blood pressure circadian rhythm and ameliorate cardiovascular injury in a rat model of metabolic syndrome?
Does long-term renal denervation normalize disrupted blood pressure circadian rhythm and ameliorate cardiovascular injury in a rat model of metabolic syndrome?
Renal denervation normalizes blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome, suggesting it as a potential therapeutic strategy.
Supports preclinical rationale in metabolic syndrome; leaves open human translation for circadian BP restoration.
By including the upregulation of the Na(+)-Cl(-) cotransporter, the renal sympathetic nerve is involved in the disruption of blood pressure circadian rhythm as well as hypertension in metabolic syndrome. Thus, RD seems to be a useful therapeutic strategy for hypertension with metabolic syndrome.
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Katayama et al. (2013) studied this question.
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