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June 5, 2011New England Journal of MedicineOpen Access

Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients

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Why the study?

Does transcatheter aortic-valve replacement improve survival at 1 year in high-risk patients with severe aortic stenosis compared to surgical aortic-valve replacement?

Population

High-risk patients with severe aortic stenosis

Comparison

Transcatheter aortic-valve replacement vs Surgical aortic-valve replacement

Follow-up

1 year

Authors

Craig R. SmithCraig R. SmithInterventional / Structural CardiologyMartin B. LeonMartin B. LeonInterventional / Structural CardiologyMichael J. MackMichael J. MackInterventional / Structural Cardiology

Discussion

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Implication

Supports TAVR as alternative for high-risk severe aortic stenosis; extends randomized evidence for less invasive valve replacement.

Structured PICO

Does transcatheter aortic-valve replacement improve survival at 1 year in high-risk patients with severe aortic stenosis compared to surgical aortic-valve replacement?

P
Population
High-risk patients with severe aortic stenosis
I
Intervention
Transcatheter aortic-valve replacement
C
Comparator
Surgical aortic-valve replacement
O
Outcome
Survival at 1 yearhard clinical

Transcatheter and surgical aortic-valve replacement provide similar 1-year survival in high-risk patients with severe aortic stenosis.

Cite This Study

Smith et al. (2011) studied this question.

synapsesocial.com/papers/69d56f8a75589c71d767d99fhttps://doi.org/10.1056/nejmoa1103510

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aortic valve replacement in octogenarians: identification of high-risk patients2010 · 80 citations
  2. 2Transapical Minimally Invasive Aortic Valve Implantation2007 · 620 citations
  3. 3Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) CoreValve ReValving System: results from the multicentre, expanded evaluation registry 1-year following CE mark approval2008 · 632 citations
  4. 42008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease2008 · 1,119 citations
  5. 5Aortic Stenosis1968 · 726 citations