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July 7, 2017PLoS ONEOpen Access

Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation

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Why the study?

Does the concomitant presence of NAFLD and systemic inflammation increase the risk of developing coronary artery calcification?

Population

Subjects with non-alcoholic fatty liver disease (NAFLD) and systemic inflammation

Design

Cohort

Follow-up

four years

Authors

JKJihyun KimPusan National UniversityDLDa Young LeeKorea UniversitySPSe Eun ParkSeoul National University

Discussion

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Implication

May support CAC risk stratification incorporating NAFLD and hs-CRP; leaves open whether targeted interventions alter progression.

Structured PICO

Does the concomitant presence of NAFLD and systemic inflammation increase the risk of developing coronary artery calcification?

P
Population
Subjects with non-alcoholic fatty liver disease (NAFLD) and systemic inflammation
I
Intervention
Concomitant presence of NAFLD and systemic inflammation (assessed by hs-CRP)
O
Outcome
Development of coronary artery calcification (CAC)surrogate

The combination of NAFLD and systemic inflammation identifies patients at increased risk for developing coronary artery calcification over a four-year period.

Cite This Study

Kim et al. (2017) studied this question.

synapsesocial.com/papers/69d56f9c75589c71d767d9bdhttps://doi.org/10.1371/journal.pone.0180118
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence of and Risk Factors for Hepatic Steatosis in Northern Italy2000 · 1,273 citations
  2. 2Nonalcoholic Fatty Liver Disease Is Associated With Coronary Artery Calcification Development: A Longitudinal Study2016 · 71 citations
  3. 3Higher association of coronary artery calcification with non-alcoholic fatty liver disease than with abdominal obesity in middle-aged Korean men: the Kangbuk Samsung Health Study2015 · 49 citations
  4. 4Nonalcoholic fatty liver disease and vascular disease: State-of-the-art2014 · 198 citations
  5. 5Characteristic sonographic signs of hepatic fatty infiltration1985 · 125 citations