Key result
NAFLD linked to ~49% higher risk of CAC development or progression.
Why the study?
Does nonalcoholic fatty liver disease increase the risk of coronary artery calcification development or progression in subjects undergoing serial CAC evaluation?
Population
1732 subjects who underwent serial coronary artery calcification evaluation in a healthcare center…
Comparison
Nonalcoholic fatty liver disease diagnosed via… vs Subjects without NAFLD
Design
Cohort
Authors
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NAFLD is independently associated with the early development of coronary artery calcification in subjects without baseline calcification, but not with its progression.
Cohort (n=1,732)
No
Does nonalcoholic fatty liver disease increase the risk of coronary artery calcification development or progression in subjects undergoing serial CAC evaluation?
Odds Ratio: 1.49 (95% CI 1.01–2.21)
Absolute Event Rate: 48.8% vs 38.4%
p-value: p=<.001
NAFLD is independently associated with the early development of coronary artery calcification in subjects without baseline calcification, but not with its progression.
Park et al. (2016) conducted a cohort in Nonalcoholic fatty liver disease (n=1,732). Nonalcoholic fatty liver disease vs. No nonalcoholic fatty liver disease was evaluated on CAC development or progression (OR 1.49, 95% CI 1.01-2.21, p=<.001). Nonalcoholic fatty liver disease was associated with a higher rate of coronary artery calcification development or progression compared to no NAFLD (48.8% vs 38.4%; P<0.001).
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