Key result
Non-alcoholic fatty liver disease is associated with significantly increased odds of coronary artery calcification progression over time (OR 1.5).
Why the study?
Coronary artery calcification progression strongly predicts cardiovascular events, but the association between NAFLD and the progression of CAC over time required assessment.
Does non-alcoholic fatty liver disease increase the progression of coronary artery calcification in adults?
Population
10,060 adults across 4 observational studies
Comparison
NAFLD vs no NAFLD
Design
Systematic review and meta-analysis of observational studies
Authors
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NAFLD warrants CV risk assessment in practice; reinforces metabolic-atherosclerosis links via Level 1 meta-analysis.
Meta-Analysis (n=10,060)
Does non-alcoholic fatty liver disease increase the progression of coronary artery calcification in adults?
Odds Ratio: 1.5 (95% CI 1.34–1.68)
p-value: p=0.001
Non-alcoholic fatty liver disease is independently associated with an increased risk of coronary artery calcification progression, highlighting its role as a marker for advancing subclinical atherosclerosis.
Koulaouzidis et al. (2021) conducted a meta-analysis in Non-alcoholic fatty liver disease (NAFLD) (n=10,060). Non-alcoholic fatty liver disease (NAFLD) vs. Participants without NAFLD was evaluated on Progression of coronary artery calcification (CAC) (OR 1.5, 95% CI 1.34-1.68, p=0.001). Non-alcoholic fatty liver disease is associated with significantly increased odds of coronary artery calcification progression over time (OR 1.5).
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