Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 27, 2020Scientific ReportsOpen Access

Association between noninvasive assessment of liver fibrosis and coronary artery calcification progression in patients with nonalcoholic fatty liver disease

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Advanced liver fibrosis and coronary artery calcification progression correlate with cardiovascular disease, but their specific association in patients with NAFLD required investigation.

Does the presence of NAFLD with advanced liver fibrosis increase the risk of coronary artery calcification progression in asymptomatic adults?

Population

1173 asymptomatic adults with CAC scores from 2007-2013

Comparison

NAFLD with different noninvasive fibrosis scores (FIB-4 and NFS) vs without NAFLD

Authors

JLJiwoo LeeHKHwi Seung KimYCYun Kyung Cho

Discussion

Loading...

Member takes

Overview

Noninvasive fibrosis scores may flag higher CAC progression risk in NAFLD; leaves open independent prediction and needs prospective validation.

Structured PICO

Does the presence of NAFLD with advanced liver fibrosis increase the risk of coronary artery calcification progression in asymptomatic adults?

P
Population
1173 asymptomatic adults evaluated between 2007-2013
I
Intervention
Presence of nonalcoholic fatty liver disease (NAFLD) with intermediate/high liver fibrosis scores (fibrosis-4 index [FIB-4] or NAFLD fibrosis score [NFS])
C
Comparator
Absence of NAFLD
O
Outcome
Coronary artery calcification (CAC) progression (defined as newly incident CAC or a ≥ 2.5-unit increase in the final CAC score square root)surrogate

Advanced liver fibrosis assessed by noninvasive markers (FIB-4, NFS) is associated with a significantly higher risk of coronary artery calcification progression in patients with NAFLD.

Cite This Study

Lee et al. (2020) studied this question.

synapsesocial.com/papers/6a7d3ce40ae9e6500d83dc99https://doi.org/10.1038/s41598-020-75266-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fibrosis stage is the strongest predictor for disease‐specific mortality in NAFLD after up to 33 years of follow‐up2014 · 2,304 citations
  2. 2Hemoglobin A1c and the Progression of Coronary Artery Calcification Among Adults Without Diabetes2014 · 117 citations
  3. 3NAFLD: A multisystem disease2015 · 3,159 citations
  4. 4Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups2008 · 3,005 citations
  5. 5The NAFLD fibrosis score2007 · 3,247 citations