Why the study?
Although liver fibrosis scores are linked to cardiovascular disease in NAFLD, their relationship with CAD severity in patients with MAFLD remained to be investigated.
Are non-invasive liver fibrosis scores associated with coronary artery disease severity in patients with metabolic dysfunction-associated fatty liver disease?
Population
1346 patients with MAFLD
Comparison
CAD (≥50% stenosis) vs non-obstructive (1-49%) vs normal coronary arteries on CCTA
Design
Single-center observational study
Key result
High non-invasive liver fibrosis scores (FIB-4 and NFS) were significantly associated with greater coronary artery disease severity in patients with MAFLD (P<0.001).
Authors
Loading...
High FIB-4/NFS scores associated with CAD severity in MAFLD; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=1,346)
No
Are non-invasive liver fibrosis scores associated with coronary artery disease severity in patients with metabolic dysfunction-associated fatty liver disease?
p-value: p=<0.001
Non-invasive liver fibrosis scores (FIB-4 and NFS) are independently associated with CAD severity and CAC scores in patients with MAFLD, suggesting they may help identify patients who would benefit from CAD screening.
Lu et al. (2023) conducted a cross-sectional in Metabolic dysfunction-associated fatty liver disease (MAFLD) (n=1,346). High liver fibrosis scores (FIB-4 and NFS) vs. Low liver fibrosis scores was evaluated on Coronary artery disease (CAD) severity (≥50% stenosis) (p=<0.001). High non-invasive liver fibrosis scores (FIB-4 and NFS) were significantly associated with greater coronary artery disease severity in patients with MAFLD (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: