February 8, 2016Hepatology Research

In NAFLD patients, age ≥66 years and FIB-4 index ≥2.09 were significant risk factors for high CAC score, and the cumulative proportion of PCI was significantly higher in those with FIB-4 ≥2.09.

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Why the study?

Is liver fibrosis (assessed by FIB-4 index) associated with coronary artery calcification and future PCI in Japanese patients with NAFLD?

Population

366 Japanese patients with chest pain or electrocardiographic abnormalities who underwent coronary CT…

Design

Cohort

Follow-up

Observation period until August 2014

Authors

HIHiroshi IshibaAichi Medical University YSYoshio SumidaInternational University of Health and Welfare SKSeita KataokaKyoto Prefectural University of Medicine

Discussion

Member takes

Overview

FIB-4 ≥2.09 was associated with higher CAC and PCI rates in NAFLD; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Is liver fibrosis (assessed by FIB-4 index) associated with coronary artery calcification and future PCI in Japanese patients with NAFLD?

Population

366 Japanese patients with chest pain or electrocardiographic abnormalities who underwent coronary CT, excluding those with known liver disorders or history of emergency coronary angioplasty. 94 patients (25.7%) had NAFLD.

Outcome

Coronary artery calcification (CAC) score of 100 AU or more (categorized as high-risk for cardiovascular events)surrogate

The FIB-4 index, a marker of liver fibrosis, is associated with coronary artery calcification and future need for PCI in Japanese patients with NAFLD.

Cite This Study

Ishiba et al. (2016) studied this question.

synapsesocial.com/papers/6a2296e4b69638e6610deedd https://doi.org/10.1111/hepr.12665

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February 8, 2016Hepatology Research

In NAFLD patients, age ≥66 years and FIB-4 index ≥2.09 were significant risk factors for high CAC score, and the cumulative proportion of PCI was significantly higher in those with FIB-4 ≥2.09.

View Full Paper

Ask AI

Bookmark

Why the study?

Is liver fibrosis (assessed by FIB-4 index) associated with coronary artery calcification and future PCI in Japanese patients with NAFLD?

Population

366 Japanese patients with chest pain or electrocardiographic abnormalities who underwent coronary CT…

Design

Cohort

Follow-up

Observation period until August 2014

Authors

HIHiroshi IshibaAichi Medical University YSYoshio SumidaInternational University of Health and Welfare SKSeita KataokaKyoto Prefectural University of Medicine

Discussion

Member takes

Overview

FIB-4 ≥2.09 was associated with higher CAC and PCI rates in NAFLD; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Is liver fibrosis (assessed by FIB-4 index) associated with coronary artery calcification and future PCI in Japanese patients with NAFLD?

Population

Outcome

Coronary artery calcification (CAC) score of 100 AU or more (categorized as high-risk for cardiovascular events)surrogate

The FIB-4 index, a marker of liver fibrosis, is associated with coronary artery calcification and future need for PCI in Japanese patients with NAFLD.

Cite This Study

Ishiba et al. (2016) studied this question.

synapsesocial.com/papers/6a2296e4b69638e6610deedd https://doi.org/10.1111/hepr.12665

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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