Key result
The presence and severity of NAFLD was associated with a significantly increased risk of coronary artery calcification compared to those without NAFLD (OR 1.36; 95% CI 1.07-1.77; p=0.016).
Why the study?
There are limited data on the association between the severity of non-alcoholic fatty liver disease and coronary artery calcification.
Is the severity of NAFLD associated with an increased risk of coronary artery calcification in the general population?
Population
545 patients in the general population
Comparison
Different severity of NAFLD vs without NAFLD
Design
Cross-sectional study
Authors
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NAFLD severity was associated with CAC after adjustment; leaves open whether it refines CV risk assessment or warrants targeted screening.
Cross-Sectional (n=545)
Is the severity of NAFLD associated with an increased risk of coronary artery calcification in the general population?
Odds Ratio: 1.36 (95% CI 1.07–1.77)
p-value: p=0.016
The severity of NAFLD is independently associated with the presence of significant coronary artery calcification, particularly in the left main coronary artery, suggesting it is a marker of increased cardiovascular risk.
Hsu et al. (2021) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=545). Nonalcoholic fatty liver disease (NAFLD) vs. No NAFLD was evaluated on Coronary artery calcification (CAC > 0) (OR 1.36, 95% CI 1.07-1.77, p=0.016). The presence and severity of NAFLD was associated with a significantly increased risk of coronary artery calcification compared to those without NAFLD (OR 1.36; 95% CI 1.07-1.77; p=0.016).
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