Key result
The presence and severity of NAFLD was associated with a increased risk of coronary artery calcification compared to those without NAFLD.
Why the study?
There are limited data on the association between the severity of non-alcoholic fatty liver disease and coronary artery calcification.
Is the severity of NAFLD associated with an increased risk of coronary artery calcification in the general population?
Cross-Sectional (n=545)
Is the severity of NAFLD associated with an increased risk of coronary artery calcification in the general population?
The severity of NAFLD is independently associated with the presence of significant coronary artery calcification, particularly in the left main coronary artery, suggesting it is a marker of increased cardiovascular risk.
Answers are grounded in this paper and cite their sources.
NAFLD severity was associated with CAC after adjustment; leaves open whether it refines CV risk assessment or warrants targeted screening.
Background and Objectives: There are limited data on the association between severity of non-alcoholic fatty liver disease (NAFLD) and coronary artery calcification. This study investigated sonographic diagnosed NAFLD and coronary artery calcium score (CAC) as detected by cardiac multidetector computed tomography in general populations. Materials and Methods: A total of 545 patients were enrolled in this study. NAFLD was diagnosed by ultrasonography examination and CAC score were evaluated by cardiac multidetector computed tomography. The association between NAFLD and artery calcium score stage was determined by logistic regression analysis and Spearman correlation coefficient analysis. Results: Of all the participants, 437 (80.2%) had ultrasonography-diagnosed NAFLD and 242 (44%) had coronary artery calcification (CAC > 0). After adjustment for cardiovascular risk factors, the risk of developing coronary artery calcification was 1.36-fold greater in the patients with different severity of NAFLD compared to those without NAFLD (OR = 1.36, 95% CI = 1.07–1.77, p = 0.016). The highest OR for separate coronary artery calcification was 1.98 (OR = 1.98, 95% CI = 1.37–2.87, p < 0.001) in the left main artery, and the risk was still 1.71-fold greater after adjustments (OR = 1.71, 95% CI = 1.16–2.54, p = 0.007). Conclusions: This cross-sectional study demonstrated that the severity of NAFLD was associated with the presence of significant coronary artery calcification, especially in the left main coronary artery, suggesting increasing the cardiovascular risk.
No takes yet. Share an insight, caveat, or question.
Hsu et al. (2021) conducted a cross-sectional in Nonalcoholic fatty liver disease (NAFLD) (n=545). Nonalcoholic fatty liver disease (NAFLD) vs. No NAFLD was evaluated on Coronary artery calcification (CAC > 0) (OR 1.36, 95% CI 1.07-1.77, p=0.016). The presence and severity of NAFLD was associated with a increased risk of coronary artery calcification compared to those without NAFLD.
Synapse has enriched 10 related papers. Consider them for comparative context: