Key result
Nonalcoholic fatty liver disease was significantly associated with the presence of coronary artery calcification in asymptomatic Chinese adults, independent of traditional risk factors (adjusted OR 1.348).
Why the study?
Is nonalcoholic fatty liver disease associated with increased coronary artery calcification in a Northern Chinese population?
Cross-Sectional (n=2,345)
No
Is nonalcoholic fatty liver disease associated with increased coronary artery calcification in a Northern Chinese population?
Odds Ratio: 1.348 (95% CI 1.03–1.765)
p-value: p=0.030
NAFLD is independently associated with the presence and severity of coronary artery calcification, particularly in women, suggesting it may serve as a marker for subclinical atherosclerosis.
NAFLD associated with CAC in Chinese adults; hypothesis-generating and requires prospective validation before clinical use.
Nonalcoholic fatty liver disease (NAFLD) has become an emerging health issue with a high prevalence in general population. The cross-sectional study was performed to investigate the association between NAFLD and coronary artery calcification (CAC) in individuals from northern city of China. A total of 2345 participants aged ≥40 (1035 men and 1310 women) were selected from the Jidong community of Tangshan city. Liver ultrasonography was used to the diagnosis of NAFLD. A 64-slice CT scanner was used to determine coronary artery calcification score (CACS), with CACS > 0 defined to be the presence of CAC. The risk level of coronary heart disease (CHD) was graded by CACS according to the 4 commonly used thresholds in clinical practice (0, 10, 100, and 400 Agatston units). NAFLD was significantly associated with CAC (crude OR: 1.631, 95% CI: 1.295-2.053, adjusted OR: 1.348, 95% CI: 1.030-1.765). The association between NAFLD and increased risk level of CHD (Crude OR: 1.639 95% CI: 1.303-2.063; adjusted OR: 1.359 95% CI: 1.043-1.770) was observed. The associations between NAFLD and CAC or increased risk level of CHD were significant in female but not in male. Our finding further confirmed the association between NAFLD and CAC, especially in Asian population.
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Wu et al. (2017) conducted a cross-sectional in Nonalcoholic Fatty Liver Disease (NAFLD) and Coronary Artery Calcification (CAC) (n=2,345). Nonalcoholic Fatty Liver Disease (NAFLD) vs. Absence of NAFLD was evaluated on Presence of coronary artery calcification (CACS > 0) (adjusted OR 1.348, 95% CI 1.030-1.765, p=0.030). Nonalcoholic fatty liver disease was significantly associated with the presence of coronary artery calcification in asymptomatic Chinese adults, independent of traditional risk factors (adjusted OR 1.348).
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