Why the study?
Does aortic valve replacement normalize LV myocardial structure and diastolic function in patients with severe aortic regurgitation?
Does aortic valve replacement normalize LV myocardial structure and diastolic function in patients with severe aortic regurgitation?
Despite normalization of macroscopic LV hypertrophy after AVR for severe aortic regurgitation, patients continue to experience persistent diastolic dysfunction and fiber hypertrophy.
Persistent diastolic dysfunction after AVR for AR warrants monitoring; leaves open whether fibrosis-targeted therapies improve outcomes.
Patients with aortic regurgitation show normalization of macroscopic LV hypertrophy late after AVR, although fiber hypertrophy persists. These changes in LV myocardial structure late after AVR are accompanied by a change in passive elastic properties with persistent diastolic dysfunction.
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Villari et al. (2009) studied this question.
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