Why the study?
Does aortic valve replacement improve left ventricular myocardial structure in patients with aortic stenosis and aortic insufficiency?
Population
27 patients with aortic stenosis and 17 patients with aortic insufficiency, plus 5 donor hearts as controls.
Comparison
Aortic valve replacement vs Pre-operative baseline and normal donor hearts
Design
Cohort
Follow-up
up to 70 months (intermediate 18 months, late 62-70 months)
Authors
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Supports partial LV reverse remodeling post-AVR; leaves open whether further regression improves outcomes in AS and AI.
Does aortic valve replacement improve left ventricular myocardial structure in patients with aortic stenosis and aortic insufficiency?
Aortic valve replacement induces significant but incomplete long-term regression of left ventricular cellular hypertrophy and fibrosis in patients with aortic valve disease.
Krayenbuehl et al. (1989) studied this question.
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