Why the study?
Does 12-LOX inhibition reduce platelet activation and thrombosis in human platelets and mouse models?
Population
Human platelets and 12-LOX-deficient mice
Comparison
Small molecule inhibitors selective for 12-LOX… vs Uninhibited human platelets and wild-type mice
Design
Preclinical
Authors
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12-LOX inhibition may limit thrombosis in models; hypothesis-generating for human antithrombotic trials.
Does 12-LOX inhibition reduce platelet activation and thrombosis in human platelets and mouse models?
12-LOX plays an important role in regulating PAR4 and GPVI-mediated platelet activation, highlighting its potential as a therapeutic target for thrombosis.
Yeung et al. (2013) studied this question.
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