The development of a novel mouse model for calcific aortic valve stenosis via direct wire injury provides a new preclinical tool for studying disease mechanisms and testing therapies.
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Enables preclinical therapy testing in a new model; leaves open translation to human calcific aortic stenosis.
We report a novel calcific AVS model to support the response-to-tissue-injury theory. This model may be a valuable tool for analyzing the mechanism of AVS and assessing therapeutic options.
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Honda et al. (2013) studied this question.
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