Why the study?
Does physiologic compensation return to normal after aortic valve replacement or is it blunted by coexistent coronary artery disease in patients with compensated aortic stenosis?
Does physiologic compensation return to normal after aortic valve replacement or is it blunted by coexistent coronary artery disease in patients with compensated aortic stenosis?
The structural and functional benefits of reverse remodeling after aortic valve replacement are disproportionately experienced by patients without coexistent coronary artery disease.
In AS patients after AVR, reverse remodeling of the supranormal systolic function parallels improvement in cardiovascular MRI-derived regression of LV hypertrophy and LV intramyocardial strain. However, discordant effects are evident after AVR, driven by CAD status, suggesting that the typical AVR benefits are experienced disproportionately by those without CAD and not by those obliged to undergo concomitant coronary artery bypass grafting/AVR.
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Biederman et al. (2005) studied this question.
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